Influence of Genetics and Mechanical Properties on Large Arteries in Man
نویسندگان
چکیده
................................................................................................................. 1 LIST OF PAPERS ........................................................................................................ 3 ABBREVIATIONS ...................................................................................................... 5 INTRODUCTION ....................................................................................................... 7 Cardiovascular disease and mortality .............................................................. 7 Structure of the arterial wall .............................................................................. 7 Mechanical properties of arteries ..................................................................... 9 Effects of aging on arteries ............................................................................... 11 Aneurysmal disease ........................................................................................... 12 Fibrillin-1 ............................................................................................................. 15 Angiotensin-converting enzyme ..................................................................... 17 AIMS ........................................................................................................................... 19 MATERIALS .............................................................................................................. 21 Ethical approval .................................................................................................. 21 Studied subjects ................................................................................................. 21 METHODS ................................................................................................................. 23 Ultrasound measurements ............................................................................... 23 Measuring mechanical properties of arteries ............................................... 26 Noninvasive blood pressure measurements ................................................ 27 Classification of cardiovascular events (Paper V) ....................................... 28 Measurement of ACE level (Paper III) .......................................................... 29 Genotyping ACE (Paper III) ............................................................................ 30 Genotyping Fibrillin-1 (Paper IV-V) .............................................................. 30 Statistics ............................................................................................................... 31
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تاریخ انتشار 2012